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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person has both ADHD and depression or anxiety, treating one condition often improves the other. Mental health professionals typically prescribe antidepressants or a stimulant for depression along with an ADHD medication. (bupropion), and Effexor, (venlafaxine), are the two most commonly used antidepressants prescribed for ADHD "off-label". These medications boost levels of neurotransmitters like norepinephrine and dopamine, which aid in improving concentration. 1. Methylphenidat