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Aging was associated with decreased number (Spearman r = - 0.598, P less then 0.0001, n = 56), decreased ACE2 (r = - 0.677, P less then 0.0004), and increased ACE activity (r = 0.872, P less then 0.0001) (n = 23) in HSPCs. Migration or proliferation of LSK cells in basal or in response to stromal-derived factor-1α in old cells is attenuated compared to young, and these dysfunctions were reversed by Ang-(1-7). Ischemia increased the number of circulating LSK cells in young mice, and blood flow to ischemic areas was recovered. These re
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