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rning was efficient and effective at improving image qualities of augmented undersampled three-dimensional (3D)- and 4D-CBCT images, and could be extremely valuable for applications in image-guided radiation therapy. An injured calcaneofibular ligament (CFL) is a major cause of ankle instability (AI). Previous research has demonstrated that the thickness of the calcaneofibular ligament (CFLT) is correlated with higher-grade sprains and ankle instability. However, inflammatory hypertrophy is distinct from ligament thickness; accordingly, we