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What Happens If ADHD is Left Untreated in Adults? Adults suffering from ADHD are susceptible to a variety of issues if the condition goes untreated. These include problems with relationships, work and mental health. Adults with untreated ADHD typically suffer from low self-esteem, as well as have a negative outlook on the world. This can cause them to feel as if they are failing at home and work. Inattention and la