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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine and other brain chemicals can increase levels. Nonstimulants, such as atomoxetine and antidepressants, operate slower than stimulants but they can be beneficial too. Comorbid conditions often affect the effectiveness of ADHD medication. Doctors should treat the most severe symptoms of any comorbid disorder first, and then examine whether the ADHD symptoms improve. Medication The most commonly used method