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ADHD Treatment For Adults Stimulants like methylphenidate, amphetamine and other brain chemicals can help increase levels. Non-stimulants like atomoxetine, antidepressants, or perform slower than stimulants but they may be as effective. Comorbid conditions can affect the response of ADHD medications. Doctors should treat the most severe symptom of any comorbid disorder first, then monitor whether the ADHD symptoms improve. Medication Medication is the most popular method of treatment for adults with ADHD. There are