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In this study, persulfate (PS) activated with microwave (MW) irradiation was used to treat strongly alkaline (pH = 12.70-12.8 wastewater containing dinitrodiazophenol (DDNP). The effects of key factors such as the PS dosage, MW output power, influent chemical oxygen demand (COD), and inorganic anions concentration were studied, and the presence of reactive oxygen species was monitored in the MW-PS process. The results showed that at a PS dosage of 6.0 g L-1, MW output power of 750 W, and reaction time of 16 min,