https://www.selleckchem.com/pr....oducts/crenolanib-cp
Rotenone upregulated LRRK2 phosphorylation and -gal levels through the activation of the p53-p21 signaling axis and downregulated Rb phosphorylation. Additionally, rotenone upregulated SA -gal activity, reactive oxygen species levels, and LRRK2 phosphorylation and inhibited lysosome activity. Rotenone-induced LRRK2 upregulation impaired the clearance of -syn fibrils. Treatment with LRRK2 inhibitor mitigated rotenone-induced cellular senescence and -syn accumulation. Rotenone-induced upregulation of LRRK2 kinase activity pro
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