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Published by Elsevier Inc.BACKGROUND Peak inspiratory flow (PIF) has been proposed as a measure to assess a patient's ability to use dry powder inhalers (DPI). However, robust quality criteria to determine a repeatability limit for measuring PIF are lacking. RESEARCH QUESTIONS What are the repeatability limits for measuring PIF? What is the relationship between PIF measured using the In-Check™ DIAL device at Diskus® (PIFD) and HandiHaler® (PIFHH) resistances? STUDY DESIGN AND METHODS Data from a randomized, controlled, phase 3 trial (study 0149) was used to