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The Most Effective ADHD Medication For Adults Stimulants are the first-choice treatment for adults suffering from ADHD. They help regulate levels of two chemical signals in the brain that regulate attention. Strattera (atomoxetine) is the most effective treatment for adhd available for adults. It is available as capsules that can be taken with food or without food. It is effective for a majority of people. lasts longer than stimulants that have less time to take effect like amphetamine a