https://romidepsininhibitor.co....m/book-diaryl-2h-azi
Missense mutations involving Gln256 had previously been reported in NS. This poly-glutamine stretch is located on helix B of this PTP domain, an area involved in stabilizing SHP2 with its autoinhibited condition. Molecular dynamics simulations predicted that modifications influencing this motif perturb the SHP2's catalytically sedentary conformation and/or substrate recognition. Biochemical information showed that replication and deletion of Gln257 variably e
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