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Distinguishing glioblastoma (GBM) and solitary brain metastasis (SBM) is vital for determining the optimal treatment. GBM and SBM present similar imaging characteristics on conventional magnetic resonance imaging (MRI). The aim of this study was to evaluate the efficacy of quantitative analysis of mean apparent propagator (MAP)-MRI for distinguishing GBM and SBM. Eighty-nine patients were enrolled. Regions of interest (ROIs), including the enhancing area (EA), peritumoural high signal intensity area (PHA), and maximum abnormal signal area (MASA), w