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BACKGROUND Despite availability of ceftolozane-tazobactam (C/T) and ceftazidime-avibactam (CZA) for several years, the individual spectrum of activity of each agent may not be widely known. We compared the activity of C/T and CZA against convenience samples of 119 ESBL-producing Enterobacterales and 60 β-lactam-resistant Pseudomonas aeruginosa clinical isolates collected from three U.S. institutions. METHODS Minimal inhibitory concentrations (MICs) for C/T and CZA were determined by broth microdilution (BMD). Molecular identification of