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ted to pathogenesis of asthma and relevant treatment, which may provide some clues for asthmatic diagnose and therapy in future. Smoking-related chronic obstructive pulmonary disease (COPD) is associated with dysregulated production of mucus. Mucins (MUC) are important both for mucus secretion and epithelial defense. We have examined the distribution of MUC1 and MUC4 in the airway epithelial cells of never-smokers and smokers with and without COPD. Mucosal biopsies and bronchial wash samples were obtained by bronchoscopy from age- and
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