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Providing enteral feeds to preterm very low birth-weight (VLBW) infants is critical to optimize nutrition, enhance growth, and reduce complications. Protocols guiding feeding practices can improve outcomes, but significant variation exists between institutions, which may limit their utility. To be most effective, protocols should be based on the best available evidence. To examine the state of the science on several key components of feeding protocols for VLBW infants. The authors searched PubMed, CINAHL, and EMBASE databases for terms