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Present studies advised that ATRA displays several neuroprotective effects and thus alleviates the disease development in a variety of neurologic diseases. Our earlier researches unearthed that the impaired retinoic acid sign reduced ALDH1A2, an essential synthetase of ATRA, within the spinal-cord of ALS mice. Right here, we evaluated the neuroprotective and neurorestorative ramifications of ATRA in a SOD1-G93A transgenic mice type of ALS. We administrated ATRA(3 mg/kg) daily through