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This chapter gives an industry perspective of how digital twins are tangibly translated, implemented, and used in a biopharmaceutical environment. Technical prerequisites and components including data modeling, the lifecycle, and different skills which are required from people to be put together and collaborate efficiently with digital twins are discussed with practical examples which have been implemented in labs and in manufacturing.Osteosarcoma is the most common primary bone tumor and usually involves the long bones. Osteosarcoma