https://www.selleckchem.com/pr....oducts/Gefitinib.htm
Moreover, induction of DDX3X-containing stress granules by external stimuli following IAV infection led to increased type I IFN signaling, suggesting that NS1 actively inhibits stress granule-mediated host responses, and DDX3X-mediated NLRP3 activation counteracts this action. Furthermore, loss of DDX3X expression in myeloid cells caused severe pulmonary pathogenesis and morbidity in IAV-infected mice. Together, our findings show that DDX3X orchestrates alternate modes of innate host defense which are critical to fight against NS1-med
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