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Comparison of postmenopausal women with and without HBC, and analysis of treatment effect on VVA were carried out. 1985 postmenopausal females without HBC and 175 with HBC had been included. VVA was verified in 90.4% of females without HBC and 91.4% of females with HBC. There were no differences in VVA signs extent or vulvovaginal vexation between groups. But, females with HBC who had finished treatment together with surgery 11-20 many years formerly versus those without HBC introduced dramatically