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Several studies have shown an association between severe asthma and serum immunoglobulins E (IgE) against Staphylococcus aureus enterotoxins (SEs). SEs-the prototypes being types A (SEA), B (SE and toxic shock syndrome toxin 1 (TSST-1)-can induce both polyclonal and specific IgE responses. The aim of the study was to evaluate the ability of SEs to induce basophil activation in severe asthmatic patients using the basophil activation test (BAT). 57 severe asthmatic patients were enrolled. BAT in response to SEA, SEB and TSST-1 was performe
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