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BACKGROUND Cognitive impairment (CI) affects about 40-70% of multiple sclerosis (MS) patients. Brain MRI explains about 33-50% of the CI variance in MS. The cognitive reserve (CR) hypothesis has been postulated to identify other factors that can account for more variance in this outcome. The objective of this study was to explore the impact of CR on cognitive performance in MS patients. METHODS A total of 526 MS outpatients were recruited (70.9% females, 41.7 ± 11.1 years old). CR was cross-sectionally assessed by the CR Index questionn
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