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Increasing patient age has been associated with worse outcomes after pituitary adenoma resection in previous studies, but the prognostic value of frailty compared with advancing age on pituitary adenoma resection outcomes has not been clearly evaluated. The National Surgical Quality Improvement Program from 2015 to 2019 was queried for data for patients aged 18 years who underwent pituitary adenoma resection (n= 1454 identified patients). Univariate and multivariate analyses of age and frailty (5-factor modified frailty index [mFI-