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Most of the antimicrobial stewardship (AMS) literature has focused on antimicrobial consumption for the treatment of infections, for surgical site infection prophylaxis and for prevention of endocarditis. The role of AMS for medical antibiotic prophylaxis (AP) has not been adequately addressed. To identify targets for AMS interventions for medical AP in adult patients. Narrative review. The various indications for medical AP and relevant evidence from practice guidelines are outlined. The following were identified as potentia