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Aim Dried blood spot (DBS) is a sampling approach that offers several advantages over plasma and whole blood (W sampling, but several factors, such as hematocrit and temperature, can adversely affect quantitation. Methodology results In an open-label, three-way crossover study in healthy subjects, we explored the correlation between DBS, WB and plasma samples, and between DBS samples from finger-prick and venipuncture blood for measuring edoxaban and its metabolite M-4 using LC-MS/MS. The methods were validated comprehensively. Th
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