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12, -1.31), 0.00001); and glycosylated hemoglobin levels (MD -1.26, 95% CI (-1.80, -0.72), 0.00001), and no serious side effects were identified. These data suggest that GQD may be an effective herbal formula in treating T2DM without serious side effects. The addition of GQD also enhances the hypoglycemic effects of metformin. However, the evidence remains weak due to methodological flaws, which may amplify the therapeutic benefit of GQD. These data suggest that GQD may be an effective herbal formula in treating T2DM without s