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05). Moreover, overexpression of miR-155 in GC exosomes improved CAC , which was characterized by fat loss, suppressed expressions of C/EPBβ, C/EPBα, and PPARγ in A-MSCs, and high expression of UCP1 ( 0.05). Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC effects. GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβ of A-MSCs, which played a crucial role in CAC. GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose dif