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Overall, the pooled prevalence rates of (moderate-to-severe) depression and anxiety among PLHIV were 16.9% [95% confidence interval (CI) 3.8%-30.0%] and 23.0% (95% CI 12.0%-34.0%), respectively. More research is needed to investigate the mechanism by which the pandemic affects the mental health of PLHIV. Support and programmes are needed to ameliorate the mental health problems in this marginalized population. More research is needed to investigate the mechanism by which the pandemic affects the mental health of PLHIV. Support and progra