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Gastrointestinal complications were increased within 1 month post FMT (OR 99.60, p 0.001). Sepsis was identified in two individuals (0.49% 95% CI 0.05-1.7%) within the first month post FMT. The risk of CDI recurrence significantly decreased post FMT compared with anti-CDI antibiotics in the multivariable model (raw-recurrence rate 9.8% vs 36%, aOR = 0.21, 95% CI 0.12-0.53, p 0.001). We show that FMT is strongly associated with a decrease in CDI recurrence compared with the usual care with generally mild complications for up to 2