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As part of a trend towards diversifying cultivated areas, varietal mixtures are regaining attention to manage diseases. Besides the epidemiological effects of varietal mixtures on pathogen propagation, little is known about the effect of intra-specific plant-plant interactions and their impact on plant response to disease. Genotypes of rice or durum wheat were grown with different conspecific neighbours and manually inoculated under conditions preventing pathogen propagation. We measured their disease susceptibility and the expression o