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In this scenario, a close collaboration among professionals in picking the best operative procedure is vital and brings to better outcomes. Isolated limb infusion (ILI) is a minimally-invasive means of delivering high-dose local chemotherapy to deal with melanoma in-transit metastases confined to a limb. The aim of this intercontinental multi-centre research would be to identify predictive aspects for toxicity and response. Data of 687 customers who underwent an initial ILI for melanoma in-transit metasta