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and modulated the gut flora in stressed mice. 919 syrup improved appetite in mice with postnatal stress by activating PPARγ to induce crosstalk with the leptin signalling pathway, this mechanism was similar to that of PPARγ agonists. 919 syrup also improved gut flora structure, and the changes in the relative abundances of the gut flora strongly correlated with the expression levels of PPARγ and leptin pathway components. 919 syrup improved appetite in mice with postnatal stress by activating PPARγ to induce crosstalk with the leptin sign