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e development of more effective life-support strategies. Critical illness is associated with rapid, specific and coordinated alterations in the cellular respiratory machinery, intermediary metabolism and redox response, with different trajectories in survivors and non-survivors. Unravelling the cellular and molecular foundation of human resilience may enable the development of more effective life-support strategies. Myocardial infarction (MI) is a leading cause of cardiovascular mortality globally. The improvement of microvascular functi