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ADHD Medications For Adults Stimulants can help regulate levels of chemical messengers in the brain that control attention. They are considered to be the first line of treatment for ADHD. Although they are not habit-forming, they can cause negative side effects, such as headaches and trouble sleeping. Your doctor may also prescribe Guanfacine (brand names Tenex and Intuniv) or Clonidine (Catapres) to d