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Lipopolysaccharide (LPS) was administered at the dose of 0.33 1 mg/kg 24 h before the shift. Mice trained to drink a high sucrose concentration responded to the shift in reward value by a reduction in the volume of sucrose consumed and a decrease in lick numbers and bout durations. Mice trained to nose poke for chocolate pellets responded to the shift by alterations in their total number of nose pokes. In both conditions, LPS had no consistent effect on the response to the shift in reward value. These findings indicate a high variability