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718). Higher serum levels of sPD-1 and sPD-L1 were present in samples of patients with more advanced brain tumours. Kaplan-Meier analysis showed that higher serum levels of sPD-1 (11.14 pg/mL) and sPD-L1 (63.03 pg/mL) might predict shorter progression-free survival times of glioma patients. This study showed that sPD-1 and sPD-L1 might be promising predictive biomarkers for the diagnosis and prognosis of glioma patients. This study showed that sPD-1 and sPD-L1 might be promising predictive biomarkers for the diagnosis and progn