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However, coupling TLC to mass spectrometry is hampered because of the difficulty to desorb the analytes through the silica areas. In this study, we used a multimodal ion source for laser desorption (LD) and low-temperature plasma (LTP) post-ionisation. Efficient desorption ended up being achieved by since the TLC plates with activated carbon. Elements of interest are analysed by spots, by outlines or by location. We show the separation of methylxa