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In conclusion, this study indicated that PPD exerts promising antidepressant-like effects in CUMS rats that are mediated in part through alterations in the dysfunction of the HPA axis, the normalization of the levels of neurotransmitters, and the suppression of neuronal apoptosis and neuroinflammation, possibly through the regulation of the SIRT1/NF-kB signalling pathway.Montelukast is a cysteinyl leukotriene (CysLT) receptor antagonist with efficacy against a variety of diseases, including asthma and inflammation-related conditions. Ho