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to guide the personalized administration of tacrolimus in early period after liver transplantation. SLCO1B1 rs2291075 could be a novel genetic locus associated with tacrolimus metabolism. The combined analysis of donor and recipient CYP3A5 rs776746, recipient SLCO1B1 rs2291075 genotypes, could be helpful to guide the personalized administration of tacrolimus in early period after liver transplantation. There is increasing evidence for the involvement of dietary bioactive compounds in the cross-talk modulation of endocannabinoid system and