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rs for a complete description of levels of evidence. Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence. Evidence shows that HIV infection may affect the survival outcome of patients with hepatocellular carcinoma (HCC). In this article, we aimed to determine whether HIV affected the overall survival of patients with HCC in China and ascertain the risk factors. Retrospective cohort study. Participants were enrolled from a single medical center in Guangzhou, China. Survival was assessed using