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0 SD. Z-scores of the control group were within the expected range. Median serum sRANKL level was 2.80, 4.52, 5.79 pmol/L in Hb S/β-thal, β-thal trait, control groups, respectively (p = 0.01. Median serum OPG level was 1.07, 0.86, 0.86 pmol/L in Hb S/β-thal, β-thal trait, control groups, respectively (p less then 0.001). β-Thalassemia trait alone is not a risk factor for osteopenia/osteoporosis and osteoporosis does not develop in premenopausal women and men younger than 50 years with Hb S/β-thal. However, as we determined lower