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Background MicroRNA-1258(miR-1258) has been shown to play an anti-cancer role in a variety of cancers, but its relationship with PTC has not been reported. The emphasis of this research was to reveal the biological function of miR-1258 in PTC and its potential mechanisms. Methods We measured miR-1258 expression in PTC cells and the transfection efficiency of miR-1258 mimic and miR-1258 inhibitor by qRT-PCR assay. CCK8 and Transwell experiments were conducted to examine the influences of altering miR-1258 expression on the viability, mig