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famata. Constructed strain accumulates twofold more riboflavin when compared to the parental strain. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.A growing body of evidence suggests that Cre recombinase can be toxic to immune cells in various experimental settings. Cre recombinase toxicity is dependent on the level of Cre activity and may also interfere with cell proliferation. Here, we compared two different published tamoxifen-inducible CD4-CreERT2 mouse lines for their suitability to study the dynamics of T-follicular helper
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