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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person suffers from both ADHD and depression or anxiety, treating the first can usually improve the second. Mental health experts prescribe antidepressants and stimulants for depression, or antidepressants in conjunction with ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most frequently used antidepressants prescribed "off-label" for ADHD. These drugs increase the levels of neurotransmitters
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