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In most cases of holoprosencephaly, the malformations are incredibly extreme that infants die before delivery. In less serious situations, infants tend to be born with normal or near-normal brain development and facial deformities that will impact the eyes, nose, and upper lip. We report 2 situations of semilobar holoprosencephaly, diagnosed in kid's Hospital of Rabat the very first one was a fetus diagnosed by ultrasonogram at 25 months of pregnancy. The second o