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The interactions between different polymorphisms showed no significant influence on the risk of investigated asbestos-related diseases. The interaction between null polymorphism and asbestos exposure decreased the MM risk (OR = 0.17; 95% CI = 0.03-0.85; p = 0.031). Our findings suggest that null genotype may be associated with a decreased risk for pleural plaques and asbestosis, may modify the association between asbestos exposure and MM and may consequently act protectively on MM risk. This study also revealed a protective effect of th
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