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Conclusions The CSSP toothpaste was far better than the fluoride control tooth paste at decreasing DH pain with benefit persisting 12 h after application. Clinical importance This novel calcium silicate and sodium phosphate tooth paste (CSSP) tooth paste is an effective twice-daily treatment whenever brushed from the teeth for dentine hypersensitivity affected individuals in comparison to cleaning with the standard fluoride paste. Twice-daily brushing provides a sustained eff