https://www.selleckchem.com/pr....oducts/Bosutinib.htm
PURPOSE A relative biological effectiveness (RBE) of 1.1 is commonly used in clinical proton therapy, irrespective of tissue type and depth. This in-vitro study was conducted to quantify the RBE of scanned protons as a function of the dose-averaged linear energy transfer (LETd ) and the sensitivity factor (α/ß)X . Additionally, three phenomenological models (McNamara, Rørvik and Jones) and one mechanistic model (Repair-Misrepair-Fixation, RMF) were applied to the experimentally derived data. METHODS Four human cell lines (FaDu, HaCat,
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