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75; 95% CI 1.14-2.7. Those with ≥10% weight loss showed the lowest HR for PDR (HR, 0.52; 95% CI 0.33-0.83), whereas those with ≥10% weight gain showed the highest HR for PDR (HR, 3.20; 95% CI 2.51-4.08). Weight gain after new-onset diabetes was associated with increased risk of ESRD and PDR whereas weight loss with decreased risk of PDR, but not ESRD. Weight gain after new-onset diabetes was associated with increased risk of ESRD and PDR whereas weight loss with decreased risk of PDR, but not ESRD. Hypertension is considered a risk fa