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This review highlights the influence of exercise and training on the inflammatory module in patients with rheumatic disease. More detailed data is needed to clarify the benefits of exercise in the context of RA and inflammation. To examine the safety and effectiveness of long-term tocilizumab treatment in elderly patients with rheumatoid arthritis (RA) and patients with age-associated comorbidities. ICHIBAN (NCT01194401) was a prospective, non-interventional study that observed adult patients with active moderate-to-severe RA in German rhe