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patients' overall recovery. [a]www.ClinicalTrials.gov[/a] NCT01626742. [a]www.ClinicalTrials.gov[/a] NCT01626742. Several proteins of the innate immune system are known to be deregulated with insulin resistance. We here aimed to investigate the relationship among circulating lysozyme (both plasma concentration and activity) and obesity-associated metabolic disturbances. Plasma lysozyme concentration was determined cross-sectionally in a discovery (Cohort 1, n=137) and in a replication cohort (Cohort 2, n=181), in which plasma lysozyme activity was al